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Phase I reactions, including oxidation, reduction, and hydrolysis, introduce or expose polar groups to increase solubility

Fine lines on forehead are mostly driven by repetitive muscle movement and UV damage

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Chaperones bind denatured or unfolded proteins thus preventing misfolding and aggregation

228 As the disease progresses (~12 years of age) and the oral microbiota becomes abundant (~35 years of age), the disease eventually develops into cystic fibrosarcoma